UDP 2NA
5′-UDP sodium salt
CAS: 21931-53-3
Molecular Formula: C9H12N2Na2O12P2
UDP 2NA - Names and Identifiers
| Name | 5′-UDP sodium salt |
| Synonyms | UDP 2NA 5′-UDP sodium salt Uridine 5'-diphosphate sodium salt URIDINE 5'-DIPHOSPHATE DISODIUM SALT Uridine 5′-diphosphate sodium salt from URIDINE 5'-DIPHOSPHORIC ACID SODIUM SALT Uridine-5' diphosphate(UDP)disodium salt uridine 5'-diphosphate sodium from*yeast URIDINE 5'-DIPHOSPHORIC ACID DISODIUM SALT Uridine 5′-(trihydrogen diphosphate) sodium salt from Saccharomyces cerevisiae,UDP sodium salt, Uridine 5′-(trihydrogen pyrophosphate) sodium salt |
| CAS | 21931-53-3 |
| EINECS | 999-999-2 |
UDP 2NA - Physico-chemical Properties
| Molecular Formula | C9H12N2Na2O12P2 |
| Molar Mass | 448.12 |
| Water Solubility | Soluble in water to 100mM |
| Solubility | H2O: soluble100 mg/mL, clear, colorless to very faintly yellow |
| Appearance | Powder |
| Color | White |
| Storage Condition | -20°C |
| Sensitive | Easily absorbing moisture |
| MDL | MFCD00006524 |
| Physical and Chemical Properties | Bioactive Uridine 5 '-dips sodium salt is a potent and selective natural agonist of the P2Y6 receptor (EC50=300 nM; pEC50 = 6.52), it is also a potent P2Y14 antagonist (pEC50 = 7.28). Uridine 5 '-dips sodium salt is an endogenous metabolite that catalyzes glucuronic acid saccharification of a variety of substrates and can be used for RNA biosynthesis. |
| Use | P2Y receptor agonist |
| Target | Human Endogenous Metabolite |
| In vitro study | Uridine 5'-diphosphate sodium salt (100 μM; for 15 min) significantly induces microglial CCL2 and CCL3 mRNA expression. Uridine 5'-diphosphate sodium salt (100 μM; 3 hours) induces chemokine expression in microglia. Uridine 5'-diphosphate sodium salt (100 μM; 0.5, 1, 3, 6 12 hours) induces expression of mRNA encoding CCL2 and CCL3 within 30 min, and such expression reaches maximal levels at 1 h, returning to basal levels at 3-12 h. UDP (10, 100, 1000 μM; 3 hours) induces a concentration-dependent increase in the expression of chemokines at both the mRNA and protein level. Uridine 5'-diphosphate sodium salt (100 μM; for 15 min) induces activation of NFATc1 and NFATc2 in microglia. RT-PCR Cell Line: Primary microglia Concentration: 100 μM Incubation Time: For 15 min Result: Significantly induced microglial CCL2 and CCL3 mRNA expression. |
UDP 2NA - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | R22 - Harmful if swallowed R68/22 - R68/20/21/22 - R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. |
| Safety Description | 36/37 - Wear suitable protective clothing and gloves. |
| WGK Germany | 3 |
| HS Code | 29349990 |
UDP 2NA - Introduction
5 '-UDP sodium salt is an organic compound with the chemical formula Na2Uridine-5'-diphosphate, also known as UDP-Na. Its nature is as follows:
1. Appearance: 5 '-UDP sodium salt is white crystalline powder.
2. Solubility: soluble in water, slightly soluble in alcohol, insoluble in non-polar solvents.
3. Stability: good stability, but at high temperature, acidic or alkaline conditions may be decomposed.
5 ′-UDP sodium salt plays an important biological function in organisms and has a variety of uses, mainly including the following aspects:
1. Biocatalyst: as a substrate and coenzyme involved in enzyme catalytic reaction.
2. Energy supply: involved in cell metabolism in the process of energy transfer and storage.
3. Signal transduction: as a signal molecule involved in intracellular signal transduction and regulation.
4. Biosynthesis: as a synthetic substrate for various important biological macromolecules in organisms.
The preparation method of 5 ′-UDP sodium salt is usually obtained by the reaction of uridine diphosphate and sodium hydroxide. The specific operation may be dissolving uridine diphosphate in an alkaline solution, and obtaining a product with higher purity through steps such as extraction and crystallization.
The following safety precautions should be taken when using and storing 5 '-UDP sodium salt:
1. Avoid contact with strong acid, strong base and oxidizing agent to prevent reaction or decomposition.
2. Avoid inhaling dust or powder, and wear appropriate personal protective equipment, such as gloves and masks, to avoid irritation to the skin and respiratory tract.
3. Store in a dry, clean, well-ventilated place, away from fire and flammable materials.
Please note that when using or purchasing 5 '-UDP sodium salt, please comply with relevant regulations and guidelines, and consult professional advice.
1. Appearance: 5 '-UDP sodium salt is white crystalline powder.
2. Solubility: soluble in water, slightly soluble in alcohol, insoluble in non-polar solvents.
3. Stability: good stability, but at high temperature, acidic or alkaline conditions may be decomposed.
5 ′-UDP sodium salt plays an important biological function in organisms and has a variety of uses, mainly including the following aspects:
1. Biocatalyst: as a substrate and coenzyme involved in enzyme catalytic reaction.
2. Energy supply: involved in cell metabolism in the process of energy transfer and storage.
3. Signal transduction: as a signal molecule involved in intracellular signal transduction and regulation.
4. Biosynthesis: as a synthetic substrate for various important biological macromolecules in organisms.
The preparation method of 5 ′-UDP sodium salt is usually obtained by the reaction of uridine diphosphate and sodium hydroxide. The specific operation may be dissolving uridine diphosphate in an alkaline solution, and obtaining a product with higher purity through steps such as extraction and crystallization.
The following safety precautions should be taken when using and storing 5 '-UDP sodium salt:
1. Avoid contact with strong acid, strong base and oxidizing agent to prevent reaction or decomposition.
2. Avoid inhaling dust or powder, and wear appropriate personal protective equipment, such as gloves and masks, to avoid irritation to the skin and respiratory tract.
3. Store in a dry, clean, well-ventilated place, away from fire and flammable materials.
Please note that when using or purchasing 5 '-UDP sodium salt, please comply with relevant regulations and guidelines, and consult professional advice.
Last Update：2024-04-10 22:39:43
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Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
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